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Breakfast Session on Aspirin Update during PHL Symposium
Prof. Akbar Chaudhry urges doctors
not to deprive their
patients of benefits of Low Dose Aspirin Therapy
We put our all ACS patients on
Aspirin, Beta Blockers,
Statins and ACE Inhibitors - Prof. Ijaz |
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MULTAN: Pakistan
Aspirin Foundation organized a Breakfast session on Aspirin Update
during the recently concluded Pakistan Hypertension League annual
symposium at Multan on February 25th 2012. It was chaired by Prof.
M. Ishaq President of PHL while the main speaker was Prof. M. Akbar
Chaudhry President of Pakistan Aspirin Foundation and Principal of
Azra Naheed Medical College, Lahore. His presentation was followed
by an interactive session in which a large number of cardiologists
were invited to share their knowledge and experience on use of
Aspirin therapy.
In his brief introductory remarks, Prof. M. Akbar Chaudhry pointed
out that Aspirin is a wonder drug which reduces morbidity and
mortality in many diseases particularly CAD, ACS and is life saving
in Acute Myocardial Infarction. He urged the health care
professionals not to deprive their patients of the benefit of Low
Dose Aspirin Therapy keeping in view its well established
indications.

Pakistan
Aspirin Foundation organized a Breakfast Session on
Aspirin Update during the PHL Symposium at Multan on
February 25th 2012. Group photograph taken on the occasion
shows Prof. Ijaz, Prof. M. Ishaq President PHL, Maj. Gen.
Ashur Khan and Prof. M. Akbar Chaudhary President of the
Foundation along with Prof. Mansoor Ahmad, Prof. Feroz
Memon, Dr. Rashid, Mr. Akhtar, Mr. Waqar, Mr. Farhan Raze
from Atco and Mr. Shaukat Ali Jawaid.
Referring to the AAUS
Study which enrolled over fourteen hundred ACS patients from
seventeen CCUs from all over the country and was conducted by
Pakistan Aspirin Foundation many years ago, he said that it showed
only 16% patients got Aspirin when they had chest pain at home, only
20.8% of family physicians prescribed Aspirin while 60% patients in
Emergency room got Aspirin and in ward it further increased to 71%.
However, on discharge unfortunately only 50% were prescribed Aspirin
which was because when the discharge slips were made by the junior
doctors, they did not give importance to Aspirin. Keeping all this
in view, Pakistan Aspirin Foundation started its CME programme for
the healthcare professionals and during the last few yeas we have
organized seminars, Update meetings , discussions all over the
country which has greatly helped to increase awareness among public
as well as the doctors community with the result that now Aspirin
use has increased a lot.

Dr. Rashid, Mr. Akhtar
Business Unit Head at Atco, Prof. M. Akbar Chaudhary
President of Pakistan Aspirin Foundation photographed
along with some members of marketing team from Atco
Laboratories which are sponsoring CME programmes of
Pakistan Aspirin Foundation. The photograph was taken
during the breakfast session on Aspirin ‘Update held at
Multan on February 25th 2012.
Prof. Ijaz Ahmad from
CPE Institute of Cardiology Multan said that they put all their ACS
patients on Aspirin, Beta Blockers, Statins and ACE Inhibitors.
Prof. Feroz Memon from Hyderabad said that patients should be
advised to immediately take a tablet of soluble Aspirin or chew the
enteric coated tablets of Aspirin when they have chest pain at home.
It is life saving and can be termed as poor man’s Statin. Prof.
Ishaq opined that all patients coming in emergency should
immediately get soluble Aspirin and first time they should be given
full dose of 325 mg and then they can be put on low dose aspirin
therapy. In literature many doses are listed i.e. 75mg, 81mg and
100mg and they are all effective. He was of the view that we need to
redo the study on Aspirin Awareness and Usage as now the figures
which we earlier had must have changed as the situation has improved
a lot. Prof. Mansoor Ahmad from Karachi said that make sure to
control the blood pressure before putting hypertensive’s on Low Dose
Aspirin therapy. Dr. Rashid Ahmad from Abbasi Shaheed Hospital
Karachi also highlighted the importance of Aspirin therapy in IHD
and in chest pain in emergency, just one tablet of 325mg of Aspirin
can prove to be life saving, he added.
Dr. Naeem opined that in primary prevention of CAD, the use of
Aspirin is still being debated at which Mr. Shaukat Ali Jawaid
Secretary General of Pakistan Aspirin Foundation pointed out that
ARRIVE study which has enrolled twelve thousand patients in five
countries including UK, USA, Germany and China started in 2009 and
final results will be available in 2013. This is by far the biggest
study on use of Aspirin in primary prevention and though lot of
evidence in favour of its use in primary prevention is accumulating,
but final answers will be available from ARRIVE study in 2013. Dr.
Abu Bakar Sheikh from Karachi remarked that we need to develop
posters, cards for display in Emergency Rooms for creating awareness
among the public about the safety and efficacy of Aspirin. Another
participant said that small booklets on Aspirin in Urdu should be
prepared which can be distributed among the patients when they are
waiting in the hospitals, clinics and in Emergency. Dr. Abu Bakar
Sheikh further remarked that enteric coated tablets of Aspirin
should be used to avoid chances of G.I. Bleeding. Major Gen. Ashur
Khan former President of Pakistan Aspirin Foundation felt that at
times patients complain of epigastric pain which has nothing to do
with chest pain and it should be kept in mind. Dr. Fazalur Rehman
from Red Crescent Hospital Hyderabad said that they were the first
one in Pakistan to start giving Aspirin to all patients coming in
emergency with chest pain.
Prof. M. Ishaq in his concluding remarks urged the healthcare
professionals to use the low dose aspirin therapy judiciously in its
well established indications. In case of Aspirin resistance, one can
use other antiplatelet agents. Earlier Mr. Shaukat Ali Jawaid
Secretary General of Pakistan Aspirin Foundation pointed out that
they were extremely grateful to M/s Atco Laboratories who have been
sponsoring our CME activities for the last many years. It is because
of their financial help and support that we have been able to
continue this awareness programme. However, keeping up the
professional ethics, we in Pakistan Aspirin Foundation do not
promote or patronize any particular brand of Aspirin. As usual this
CME meeting was also sponsored by Atco Laboratories and Mr. Farhan
Raza their Product Manager along with his team had worked hard for
its success. Mr. Akhtar Business Unit Head in Atco Laboratories, Mr.
Waqar from the marketing department and others were also present on
this occasion.
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Aspirin Update seminar at Dera Ghazi Khan
People with high risk of CAD,
those with family history of
heart disease and Type-2 diabetics should be put on
Low Dose Aspirin therapy-Prof. Akbar Chaudhry
Blood Pressure should be controlled
before prescribing
hypertensive’s LDA - Dr. Yousuf
Low Dose Aspirin 75mg daily is quite useful in
recurrent miscarriages - Dr. Humaira Shakeel |
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DERA GHAZI KHAN: All
people with high risk of coronary artery disease, those with family
history of heart disease and all type 2 diabetics should be put on
Low Dose Aspirin therapy if there are no contra indications. Enteric
coated aspirin should be preferred because of its safety in long
term use and any dose 75mg, 81mg and 100mg is equally effective.
This was stated by Prof. M. Akbar Chaudhry a noted physician,
President of Pakistan Aspirin Foundation who is Principal and Prof.
of Medicine at Azra Naheed Medical College, Lahore. He was making a
presentation at a seminar organized by Pakistan Aspirin Foundation
in collaboration with Pakistan Medical Association Dera Ghazi Khan
here on February 23rd 2012. Other speakers who shared their views on
medical uses of Aspirin on this occasion included an eminent local
physician Dr. Mohammad Yousuf and Dr. Humaira Shakeel consultant
obstetrician and gynaecologist. Dr. Tahir Farid Turk General
Secretary of PMA Dera Ghazi Khan and his team and worked hard and
made excellent arrangements to organize this meeting which was very
well attended and the participants showed keen interest in this
academic activity by actively participating in the discussion.

Dr. Gul Mohammad Shamsi senior
most physician of Dera Ghazi Khan presenting flower
bouquet to Dr. Mohammad Yousuf and Prof.M. Akbar Chaudhry
at a seminar on Medical Uses of Aspirin organized by
Pakistan Aspirin Foundation in collaboration with PMA Dera
Ghazi Khan here on February 23, 2012.
Prof. Akbar Chaudhry
in his presentation first talked about the burden of high prevalence
of cardiovascular disease in the world and in Asia in particular and
then traced the history of discovery of Aspirin in early 19th
century. Speaking about the known risk factors for CAD he mentioned
dyslipidemia, obesity, metabolic syndrome, smoking, high blood
pressure, etc. He laid emphasis on preventive measures starting with
prevention of smoking, regular exercise, use of healthy diet, weight
control, blood pressure control, lipid control and control of blood
glucose and finally highlighted the safety and efficacy of low dose
Aspirin therapy.
Aspirin is being used for a variety of diseases but its major use
these days is in cardiovascular disease which accounts for 37.6%.
Aspirin is also referred to as Poor Man’s Statin. A single tablet of
325mg soluble aspirin can prove life saving in heart attacks as it
reduces the mortality by almost 23%. Enteric coated tablets can also
be chewed if need be. If Aspirin is combined with clopidogrel, the
reduction in mortality is reported to be up to 44%. However, if
Aspirin is contra indicated, other anti platelet agents can be used.
Aspirin, Prof. Akbar Chaudhry remarked remains the mother
antiplatelet which is the most cost effective therapy and reduces
morbidity and mortality in CAD. There have been numerous studies to
prove this but even then Aspirin remains underused all over the
world Pakistan being no exception. That is why Aspirin Foundations
around the world including Pakistan Aspirin Foundation has started
this awareness campaign to educate the healthcare professionals and
promote its use in well established indications. Today’s meeting, he
said, was a part of the CME programme which the Pakistan Aspirin
Foundation has been running for the last many years. Apart from
secondary prevention of CAD, Aspirin use in prevention of stroke is
also well established. To prevent recurrent attacks of Stroke, the
patient should be put on 150mg enteric coated Aspirin therapy
indefinitely. However, after the age of eighty years its use is not
advocated. Since in Pakistan life expectancy is about ten years
less, hence here it should be used with caution after the age of
seventy years.

Dr. Tahir Farid Turk General
Secretary PMA D. G. Khan, Dr. Yousuf, Prof. M.Akbar
Chaudhry, Mr. Akhtar Business Unit Head in Atco, Mr. Waqar
from Atco Labs and others photographed at the Seminar on
Medical Uses of Aspirin held here recently which was
sponsored by Atco Laboratories.
Regular use of
Aspirin has more protective effect in women as regards stroke. So
far well established uses of Aspirin has been confirmed in Acute
Myocardial Infarction, Acute Coronary Syndrome, secondary prevention
of MI,TIAs and Stroke, prophylaxis for thrombo embolism following
different interventional procedures, surgery, hypertension and
diabetes. A large primary prevention trial in CAD known as ARRIVE
which has enrolled twelve thousand patients in five countries
started in 2009 and the final results will be available in 2013. He
then referred to various studies which have shown reduction in
non-fatal MI, Non-fatal stroke, and reduction in total
cardiovascular mortality besides other important vascular events. He
also referred to the results of AAUS study conducted by Pakistan
Aspirin Foundation many years ago which showed that Aspirin was very
much underused, even 50% of ACS patients on discharge were not
prescribed Aspirin therapy. He also referred to some recent reports
which say that Aspirin fails in primary prevention of asymptomatic
peripheral disease and diabetes. A Meta analysis has showed that
Aspirin reduced the risk of MI in men by 43% with no significant
effect in women. Some studies say that the expected benefits of
aspirin in diabetes might not exceed the risk of major bleeding;
hence its role in such patients is controversial. All this shows
that the physicians have to make choice of use of low dose aspirin
therapy by looking at the individual patients keeping in view his
medical history. Replying to a question, he said that aspirin
therapy should be stopped a week before expected surgery.
Finally he referred to the new and emerging indications of Aspirin
in Dementia, Alzheimer’s disease, colorectal cancer, insulin
resistance, pulmonary embolism, gastric cancer and so on. Hence,
this drug which is over hundred years old keeps us surprising with
the new and more indications being reported by research scientists
all over the world.
Earlier Dr. Mohammad Yousuf, Consultant Physician in his brief
presentation on Aspirin therapy talked about the use of Aspirin as
antipyretic, for relief of body aches, pain, fever, arthritis tough
it does not alter the disease process in arthritis. He also referred
to its use in CAD, prevention of MI, colorectal cancer, and
pregnancy induced hypertension etc. While using Aspirin one must be
careful of its side effects like urticaria, edema, about 10% of
asthamatics might become worse hence avoid it in these patients,
allergic rhinitis. Major side effects are gastric, nausea vomiting,
bleeding. Hence it should be avoided in patients with known peptic
ulcer, bleeding ulcers. It should also be avoided in children
because of Rye’s syndrome. Aspirin remains a good therapy in tension
type headaches, body aches, it is an effective anti-inflammatory in
rheumatoid arthritis, and it remains a gold standard in CAD and
ischaemic strokes. Before using Aspirin in hypertensives, one must
control the blood pressure first, he remarked.
Dr.Humaira Shakeel consultant obstetrician and gynaecologist in her
brief presentation highlighted the safety and efficacy of low dose
aspirin therapy in recurrent miscarriages. She also talked about its
pathophysiology. It can be used in combination with LMWH. Pregnant
women treated with low dose aspirin therapy had no eclampsia and
they had no PPH, she added.
Mr.Shaukat Ali Jawaid General Secretary of Pakistan Aspirin
Foundation talked about the history and accomplishments of the
Foundation since its inception and also highlighted its CME
activities. Dr. Tahir Farid Turk General Secretary of PMA welcomed
the guest speakers and the participants to the meeting. He asked
them to be punctual and promised that as today, in future too they
will start their programme in time and won’t take more than two
hours, hence they should try to be in time. He also thanked M/S Atco
Laboratories and their management for providing this opportunity to
update their knowledge on Aspirin and from today I will be using
enteric coated low dose Aspirin therapy regularly and he advised all
his colleagues as well to do the same to avail its benefits.
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Aspirin Update
seminars at Burewala and Leyyah
Low Dose Aspirin Therapy being
increasingly used by
high risk group for Primary prevention of CAD, ACS
Healthcare professionals commend efforts
of Pakistan Aspirin Foundation
to promote the use of Aspirin in its well
established indications |
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BUREWALA: Pakistan
Aspirin Foundation continues its Continuing Medical Education programme
for healthcare professionals to create awareness and promote the use of
Aspirin in its well established indications by organizing seminars in
various cities all over the country. The latest in this series of
seminars was the meetings organized at Burewala and Leyyah. Prof.
M.Akbar Chaudhry FRCP, FCPS, Principal, Azra Naheed Medical College
Lahore who is also President of Pakistan Aspirin Foundation was the
guest speaker. The meeting held at Burewala on May 11th was organized in
collaboration with Pakistan Medical Association Burewala which was
largely attended. It was chaired by Dr. Naseeer Mansoor along with Dr.
Munir Ahmad Sindhu President of local PMA.

Prof. M. Akbar Chaudhry President Pakistan Aspirin
Foundation, Mr.Shaukat Ali Jawaid, Dr. Imran Samiullah, Dr. M. Yousuf
and Dr. Zafar Iqbal speaking at the seminar on Aspirin organized by
Pakistan Aspirin Foundation in collaboration with PMA Burewala on May
11th2011.
The meeting was conducted by Dr. Zafar Iqbal Mirza, General Secretary
PMA Burewala. It started with recitation from Holy Quran by Dr. M.
Yousuf consultant paediatrician. Prof. M. Akbar Chaudhry in his
presentation discussed in detail the well established indications as
well as the emerging new indications for use of low dose aspirin
therapy. He pointed out that Aspirin despite being the most economically
priced antiplatelet agent whose safety and efficacy has been well
documented remains underused all over the world and Pakistan was no
exception. However, recent reports suggest that because of the efforts
being made by the Foundation, use of low dose Aspirin Therapy has
increased among the high risk group of patients for primary prevention
of Coronary Artery Disease, Acute Coronary Syndrome, control of
hypertension, primary and secondary prevention of acute myocardial
infarction as well as Stroke and TIAs.

Pakistan Aspirin Foundation organized a seminar on An
Update on Aspirin at Leyyah on May 12th 2011. Pictures taken
on the occasion shows from (L to R) Dr. Mohammad Sadiq MS DHQ Hospital
presenting gifts to Dr. Afzal Dhandla (Chief Guest) and Prof. M. Akbar
Chaudhry President of Pakistan Aspirin Foundation. On right the group
photograph shows Mr. Farhan Raza Group Product Manager Atco, Dr. Zafar
Iqbal Malkani, Mr.Shaukat Ali Jawaid, Prof.Akbar Chaudhry, Dr. Afzal
Dhandla and Dr. Shafiqur Rehman Chishti consultant cardiologist who was
the local co-coordinator of this CME programme.
Cardiovascular diseases, he pointed out, remains the No. 1 cause of
death globally and there is higher prevalence of CAD in urban areas as
compared to rural areas. By 2020 it is feared that CAD will become the
leading cause of death in developing world causing 7.8 million deaths
annually. As regards CVD deaths in Pakistan, it is estimated that in
2010 it must have accounted for 675 thousand deaths. While some of the
risk factors like gender etc., cannot modified but there are modifiable
risk factors which include Hypertension, diabetes mellitus, dyslipidemia,
obesity, metabolic syndrome, smoking etc. Aspirin is recommended by
American Heart Association for all apparently healthy individuals at
risk of CAD for primary and secondary prevention of myocardial
infarction. Risk interventions include smoking cessation, physical
activity, diet therapy, weight control, blood pressure control, and
lipid and diabetes control.
Speaking about the benefits of Aspirin, Prof. Akbar Chaudhry said that
it reduces the risk of MI by 33%, risk of first stroke by 25% and risk
of CVD death by about 17%. As regards secondary prevention, serious
vascular events are reduced by 46% in unstable angina, 33% in stable
angina, 23% in peripheral arterial disease and 53% in patients
undergoing angioplasty. However, the irony is that the Aspirin Awareness
and Usage Study (AAUS) conducted by Pakistan Aspirin Foundation a few
years ago at 17 Coronary Care Units all over Pakistan which involved
over fourteen hundred patients had revealed that only 16% of patients
took Aspirin at home when they had chest pain, 20.8% of these patients
were prescribed Aspirin by their family physicians and only 50% of the
ACS patients were prescribed Aspirin at the time of discharge. After
these results we in the Pakistan Aspirin Foundation intensified our
efforts to educate and update the healthcare professionals on the safety
and efficacy of Aspirin by organizing such seminars. Now latest reports
suggest that the situation is improving and use of Low Dose Aspirin
therapy has significantly increased.

Pakistan Aspirin
Foundation in collaboration with PMA Burewala organized a seminar on
Aspirin Update on May 11th 2011. Picture taken on the occasion shows
from (L to R) Dr. Zafar Iqbal, Mr.Shaukat Ali Jawaid, Dr. Imran
Samiullah, Dr. Munir Ahmad Sindhu President PMA Burewala, Prof Akbar
Chaudhry and Dr. Naseer Mansoor.
It is extremely useful and can prove life saving if just one tablet of
325 mg Aspirin is taken within six hours of acute myocardial infarction.
In acute emergency either the patients should be advised to use soluble
aspirin or chew at least four enteric coated tablets of Aspirin if it is
in 75mg. It is as effective as streptokinase and will prevent over 20%
deaths. If Aspirin is used in combination with clopidogrel, the risk
reduction is further increased by 20%. Dual antiplatelet therapy is
usually used after interventional procedures, angioplasty and stenting.
For secondary prevention of stroke the recommended dose of Aspirin is
150mg daily. Similarly all Type-2 diabetics should also be put on low
dose aspirin therapy if there are no contraindications. If aspirin is
contra indicated, other antiplatelet agents can be used. It also helps
prevent stent thrombosis. Talking about the emerging indications for use
of Aspirin therapy Prof. Akbar Chaudhry mentioned colorectal cancer,
dementia, Alzheimer’s disease, pulmonary embolism, DVT, insulin
resistance, renal cancer besides gastric cancer etc.
The presentation was followed by lively discussion. Responding to
various questions Prof. Akbar Chaudhry said that in case of minor
surgery, Aspirin therapy can be stopped five days before but in case of
major surgery, stop aspirin therapy at least seven days before planned
surgery. There are no reports of its efficacy in breast cancer, it is
not recommended for use in children.

Picture from (L to R)
shows Dr. Naseer Presenting shield to Prof. Akbar Chaudhry and Dr. Saeed
presenting shield to Dr. Naseer while on extreme right Dr. Imran
Samiullah is presenting shield to Mr. Shaukat Ali Jawaid General
Secretary of Pakistan Aspirin Foundation at the seminar on An Update on
Aspirin organized by PAF in collaboration with PMA Burewala on May 11th
2011.
Earlier Mr. Shaukat Ali Jawaid General Secretary of Pakistan Aspirin
Foundation highlighted the aims and objectives besides the
accomplishments of the Foundation so far. He also pointed out that
though still there is some controversy regarding use of Aspirin for
primary prevention of CAD but the largest every trial in Primary
Prevention ARRIVE which has enrolled twelve thousand patients in five
countries including China and USA was initiated in 2009. Its findings
will be available by 2013 which will give answer to this question.
Dr. Imran Samiulllah consultant cardiologist who was the local organizer
and co-coordinator in his welcome address thanked Pakistan Aspirin
Foundation for holding this informative meeting in Burewala. He also
briefly highlighted the safety and efficacy of Aspirin. Later mementoes
to the guests were presented by Dr. Naseer and Dr. Munir Ahmad Sindhu.
PMA Burewala, it may be mentioned here is quite active and regularly
holds such academic sessions to keep its members informed and update on
latest developments in medicine thereby improving the patient care.

Dr. Munir Ahmad Sindhu President
Pakistan Medical Association Burewala presenting an
appreciation letter to Mr.Farhan Raza Group Product Manager
Atco for sponsoring the CME programme on An Update on Aspirin
held on May 11th 2011.
Meet at Leyyah
The seminar at Leyyah was
organized on May 12th and it was jointly chaired by Dr. Zafar Iqbal
Malkani Consultant Physician at the local DHQ Hospital, Dr. Afzal
Dhandla a well known skin specialist who hails from a very influential
political family in the area and Dr.Shafiqur Rehman Chishti consultant
cardiologist who was also the local organizer and co-coordinator.
Presentations by the guest speakers Prof. M.Akbar Chaudhry and Mr.
Shaukat Ali Jawaid were followed by lively discussion.
Responding to various questions Prof.Akbar Chaudhry said that
Clopidogrel can be used for one year and then the patients should be
continued on low dose Aspirin 75-100ng daily indefinitely. Since most of
the strokes are ischaemic and not haemorrhagic, even in case CT scan is
not available, one tablet of Aspirin in case of chest pain would not do
much harm but it might save the patients life. However, when you are
using Aspirin in combination with clopidogrel, be mindful of the side
effects as there are increased chances of bleeding. For hypertensive’s,
they must control their blood pressure first and then start using
Aspirin, he added. Proton Pump Inhibitors do have some problems with
clopidogrel as regards drug interactions but no such problems are seen
with Aspirin, he remarked.
Dr. Shafiqur Rehman Chishti in his welcome address highlighted the life
saving properties of Aspirin if taken immediately within six hours of
chest pain. It is extremely useful in primary and secondary prevention
of AMI, CAD, Stroke and TIAs. Dr. Zafar Iqbal Malkani thanked Prof.
Akbar Chaudhry and Pakistan Aspirin Foundation to have come all the way
to Leyyah to hold this informative meeting which has benefitted us all.
Many of the participants felt that before this they were not aware of
the fact that Aspirin is so useful in a wide range of diseases.
Dr.Afzal Dhandla in his concluding remarks said that he himself will
start taking low dose aspirin therapy from today and will recommend it
to all his patients, friends and well wishers. This is a wonderful drug
which is economically priced but offers a lot of benefits. He advised
the participants to advise their patients to stop smoking, reduce
weight, control their blood pressure and start taking low dose aspirin
therapy on regular basis.
Organizers at Burewala as well as Leyyah expressed their thanks to Atco
Laboratories for sponsoring these meetings. PMA Burewala also presented
a letter of appreciation to Mr.Farhan Raza Group Product Manger in Atco
laboratories as a token of appreciation.
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Prevention of CAD, MI and
Stroke
Physicians advised not to deprive
deserving
patients
of benefits of Low Dose Aspirin therapy |
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KARACHI: Eminent cardiac
physicians participating in the panel discussion in the Break Fast
session on Aspirin during the Pakistan Hypertension League annual
seminar held on Sunday January 16th advised the physicians not to
deprive the deserving patients of the benefits of Low Dose Aspirin
Therapy. There is lot of data now available to prove that regular use of
low dose Aspirin 75-100mg per day significantly reduces morbidity and
mortality in cardiovascular diseases besides preventing CAD, Myocardial
Infarction and stroke. Hence, all high risk patients should be put on
Aspirin therapy unless there is some contra indication.

Pakistan
Aspirin Foundation organized a Breakfast session on Aspirin
update during the recently held annual symposium of Pakistan
Hypertension League on January 16th 2011. Group photograph
taken on this occasion shows from (L to R) Mr. Farhan Raza
Product Manager Atco, Mr. Shaukat Ali Jawaid General Secretary
PAF, along with members of the Experts Panel Major Gen. Ashur
khan, Dr. Abu Bakar, Prof. Ejaz Ahmad Vohra and Dr. Syed Imran
Ahamd .
The moderator in the
session was Dr. Abu Bakar Sheikh while other panelists included Major
Gen. Ashur Khan, Prof. Ejaz Ahmad Vohra, Dr.Syed Imran Ahmad, Dr. Amir
Hameed, Prof. Khandkar from Bangladesh and others. This interactive
discussion was attended by many other physicians as well who were
present on this occasion. Dr. Abu Bakar Sheikh in his introductory
remarks said that approach in high risk patients particularly of stroke
will be different. However, it is essential to take care of the all
important risk factors and modify the risks as far as possible. Those
who have an MI risk of 10% are considered mild, those between 10-20%
risks are considered moderate risk but more than 20% are grouped as high
risk cases. We intervene to modify the risk with pharmacological and
non-pharmacological interventions. Aspirin is extremely effective in
secondary prevention but in primary prevention it is still being
discussed in certain conditions and one has to be careful of the risk of
GI bleeding.
Dr.Syed Imran Ahmad said that this risk of bleeding has to be
calculated. Different scales are now available to calculate this risk.
Mr.Shaukat Ali Jawaid pointed out that the risk of GI bleeds with
Aspirin is much less as compared to various NSAIDs which are being
routinely used. Referring to the Aspirin Awareness and Usage Study (AAUS)
he said that this revealed that only 16% of patients with ACS took
Aspirin at home, only 20% Family Physicians prescribed Aspirin to these
patients but what was more criminal was the fact that on discharge from
CCU only 50% of the patients were prescribed Aspirin along with other
medications. Prof. Ejaz Ahmad Vohra said that one must rule out diabetes
mellitus and if the patient is diabetic, then he or she must be put on
Aspirin and Stations. Some patients may not tolerate combination of
Aspirin and Clopidogrel; hence this must be kept in mind. It is
advisable to take Aspirin therapy at night.
Dr. Amir Hameed said that at times hypertensive patients are prescribed
Aspirin . In the elderly it is OK but in young patients, one has to be
careful. Mr. Shaukat Ali Jawaid pointed out that Pakistan Aspirin
Foundation always recommends that first the blood pressure must be
brought under control and only then the patients should be prescribed
low dose Aspirin therapy. Enteric coated LDA therapy is very safe and
effective in long term use. Prof. Ejaz Ahmad Vohra said that in the
elderly if they are taking Statin and Aspirin, one must control
hypertension first because the risk of bleeding is also higher in this
group. He also remarked that in Asia, almost 30% of strokes are
hemorrhagic in nature as compared to just 1o-15% in the West. Aspirin is
a very useful drug but it should not be misused. Recent studies have
also shown its efficacy in colorectal cancer. Prof. Khandkar from
Bangladesh opined that first high blood pressure has to be controlled
before prescribing low dose aspirin therapy. Maj. Gen. Ashur Khan felt
that a blood pressure of 140-150 was considered OK in the elderly in the
past but now the recommendation is the same i.e. 130-135 SBP. Some
family physicians, he further stated, prescribed Aspirin as treatment
for hypertension which is not the correct approach, it has to be
combined with an antihypertensive agent.
Dr. Abu Bakar Sheikh then presented different case scenarios of patients
in different age groups and it was suggested that for prevention of CAD,
TIA and stroke low dose aspirin therapy is effective but in the very old
patients, it should be avoided particularly after the age of eighty
years. Quality of life and span of life also came under discussion and
Dr. Amir Hameed pointed out that different physicians have a different
approach but many feel that quality of life is much more important than
life span. Hence the physicians should ensure quality of life to the
patients.
Earlier Mr. Shaukat Ali Jawaid General Secretary of Pakistan Aspirin
Foundation highlighted the aims, objectives and accomplishments of the
foundation so far. He pointed out that apart from holding seminars on
Aspirin Update in different cities; such interactive sessions are also
organized in collaboration with different professional societies like
PCS, PHL, and PSP etc. Mr.Farhan Raza Product Manager Atco Laboratories
which are sponsoring these CME programms of Pakistan Aspirin Foundation
welcomed the participants and thanked the panel of experts for their
valuable comments and suggestions to promote the use of low dose aspirin
in its well established indications.
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Pakistan
Aspirin Foundation to revise its
guidelines on Medical Uses of Aspirin
Follow up study regarding Awareness and
Usage of Aspirin also being planned
HYDERABAD: A meeting of Pakistan
Aspirin Foundation was held here on December 25th during the Pakistan
Cardiac Society’s annual conference which discussed many important
issues. Those who were present in the meeting included Prof. M. Akbar
Chaudhry (President), former Presidents i.e. Prof. Abdus Samad, Major
Gen. Ashur Khan, Dr. Maqbool H. Jafary besides Prof. M. Ishaq, Prof.
S.H.Shafqat, Dr. Khawar Kazmi, Prof. Shahryar Sheikh, Prof. Mansoor
Ahmad and Mr. Shaukat Ali Jawaid. Mr.Akhtar from ATCO Laboratories
which are sponsoring all CME programmes of the Foundation was also
present on special invitation.
The meeting reviewed the activities and progress of the Foundation so
far. It was decided that the Consensus Report on the Medical Uses of
Aspirin should be revised and updated. Prof. Abdus Samad Chairman of
the Experts Panel was entrusted this responsibility to update this
document. On a suggestion from Dr. Maqbool H.Jafary it was also
decided to conduct a follow up study on Awareness and Usage of Aspirin
to find out the impact of the CME and Awareness programmes being
organized by the Foundation for the last many years. Dr. Maqbool H.
Jafary along with Prof.M.Ishaq will develop the study protocol for
this purpose.
Prof.Shahryar Sheikh referred to various studies wherein now the use
of Aspirin in primary prevention is also being challenged and
contested. However, Prof. Abdus Samad remarked that till today no
study has refuted the safety and efficacy of Aspirin in reducing the
morbidity and mortality in various cardiovascular disorders and this
remains the mother antiplatelet agent which is quite economical and
affordable besides being easily available every where. Mr. Akhtar
briefed the participants about the measures they have taken to ensure
quality of this preparation. The Quality Assurance Department, he
said, is very strict and all efforts are made to ensure sustainable
quality control in all batches besides the proper storage of the
finished product. On Dr. Khawar Kazmi’s suggestion it was stated that
we have already added the world of Forum for Thrombosis and
Atherosclerosis under the Foundation. However, since all over the
world, the organizations active in this field are named as Aspirin
Foundations, hence we also decided to name it as Pakistan Aspirin
Foundation. Prof. Abdus Samar disclosed that now Aspirin has been
included in the category of orphan drugs, since there is not much
profit and non one is interested to promote its use.
The participants expressed their appreciation to Atco Laboratories for
sponsoring the CME programmes to create awareness thereby promoting
the use of Aspirin in its well established indications. It was also
decided to hold such meetings in Jacobabad, Shikarpur, RahimYar Khan,
Dera Ghazi Khan and Sukkur in the days to come. The participants who
are all distinguished physicians and are always among the invited
speakers at different conferences were also requested to utilize every
available opportunity to talk about Aspirin thereby promoting its
usage.
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Aspirin Update seminar at
Gojra
Prof. Akbar Chaudhry urges
healthcare
professionals to promote the use of Aspirin
This economically priced mother
anti-platelet agent reduces morbidity
and mortality in many disorders including cardiovascular diseases
Dr.
Obaidur Rahman reminds the doctors to uphold professional ethics |
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From our
correspondent
GOJRA (FAISALABAD): Pakistan Aspirin Foundation continues its
Continuing Medical Education programme for the healthcare
professionals updating them in the use of Aspirin in its well
established indications. In this on-going academic programme, a
seminar on Aspirin Update was also organized here on October 21st
which was very well attended. Dr. Obaidur Rahman Consultant
Physician and Cardiologist was the local organizer and the meeting
was held in collaboration with the local Pakistan Medical
Association. Prof. M. Akbar Chaudhry Principal Continental Medical
College who is also President of Pakistan Aspirin Foundation was the
guest speaker who in his presentation called upon the healthcare
professionals in general and Family Physicians in particular to
promote the use of Aspirin the economically priced mother
anti-platelet agent in its well established indications. Despite
proven safety and efficacy in a wide range or disorders, Aspirin
still remains under-used all over the world and situation was no
better Pakistan, he added.
Pakistan Aspirin Foundation in
collaboration with PMA Gojra organized a seminar on “An Update
on Aspirin” at Gojra on October 21st 2010. Picture
taken on the occasion shows from (L to R) Prof. M.Akbar
Chaudhry President PAF presenting bouquet to Dr. Mian Mahmood
ul Hassan while on right Mr.Shaukat Ali Jawaid GS of PHL is
presenting bouquet to Dr. Riaz A. Khan GS PMA Gojra and Dr.
Obaidur Rehamn.
He also referred to
the Aspirin Awareness and Usage Study (AAUS) conducted by Pakistan
Aspirin Foundation which enrolled over fourteen hundred Acute
Coronary Syndrome patients from seventeen Coronary Care Units across
the country. This showed that only 20% of the Family Physicians
prescribed Aspirin to the patients at the time of acute myocardial
infarction while only 16% got Aspirin at home. This is a very dismal
picture which shows that we need to create more awareness not only
among the medical profession but public as well regarding the
usefulness of this wonderful drug. One full tablet taken immediately
after AMI, can prove life saving and numerous studies have
documented 23% reduction in mortality in such a situation. In case
Aspirin is combined with streptokinase, the risk reduction is over
40%. Aspirin is readily available every where and it is very
economically priced, hence the physicians must educate their
patients and general public that in case of chest pain, they must
take one tablet of Aspirin and chew it or use soluble Aspirin.
All CCU patients on discharge must be put on Low Dose Aspirin
therapy 75mg per day. Similarly all Type-2 diabetics, those patients
who have had interventional cardiac procedures and stroke should be
put on Low Dose Aspirin therapy unless there is some
contraindication. Enteric coated Aspirin is safe and also effective
even in long term use that is why it is and should be preferred. He
also referred to the new and emerging indications for use of Aspirin
like Pre-eclampsia, Dementia, Alzheimer’s disease, Colo-rectal
Cancer, Gastric and Esophageal cancer, insulin resistance and so on.
Almost every day there is some new discovery of its uses and this
wonderful drug which has been in clinical use for now over one
hundred ten years continues to surprise us all. Once hypertension is
controlled, all hypertensive’s also needs to be put on low dose
aspirin therapy. However, in those patients where Aspirin is contra
indicated, other antiplatelet agents should be used. Combination of
Aspirin and Clopidogrel further enhances the risk reduction in
cardiac patients. Now there is lot of data available supporting the
use of Aspirin even in primary prevention of Coronary Artery Disease
but the results of largest ever Primary Prevention Trial (ARRIVE)
which will enroll over twelve thousand patients from five countries
will be available in 2013 which it is hoped will conclusively prove
the safety and efficacy of Aspirin even in primary prevention of
CAD.
Group photograph taken
during the seminar on Aspirin at Gojra shows from (L to R)
Dr. Riaz A. Khan General Secretary PMA Gojra, Mr. Akhtar
General Manager Marketing from Atco Labs, Dr. Mian
Mahmoodul Hassan and Prof. M. Akbar Chaudhry President of
Pakistan Aspirin Foundation.
Responding to various
questions from the audience, Prof Akbar Chaudhry said that use of
Aspirin must be stopped at least five to seven days before elective
surgery. Aspirin is not recommended in all pregnant patients but
only in pregnancy induced hypertension. One of the participants
advised the family physicians to use few drugs but they must know
their price and side effects, interactions. Re-bleeding has also
been noted in some patients after stenting and angioplasty, and
these patients need to be carefully managed.
Mr. Shaukat Ali Jawaid General Secretary of Pakistan Aspirin
Foundation highlighted the aims, objectives and achievements,
accomplishments of the Foundation since its inception. It is a very
democratic body and its membership is open to physicians and general
public. He also quoted Scottish Physician Prof. Peter Elwood the
pioneer research scientists who for the first time clinically proved
and reported in 1974 that Aspirin can be a life saving drug in AMI.
Peter Elwood says that we all must keep Aspirin with us all the
time, at clinic and at homes as we ourselves, our friends of family
members may need it any time and in case of an emergency i.e. Acute
Myocardial Infarction it can save live. He thanked M/s Atco
Laboratories for their generous sponsorship of these academic
programmes and hastened to add that keeping up the professional
ethics; they do not patronize or promote any particular brand of
Aspirin. It is up to the medical profession to make their choice.
Earlier Dr. Obaidur Rahman in his welcome address advised the
healthcare professionals to uphold professional ethics. Unethical
practiced indulged in by some members of the medical profession was
bringing bad name to the entire doctors community. Medicine is a
noble profession and we all must practice ethical medicine. He
thanked Pakistan Aspirin Foundation for selecting Gojra for one of
their CME meetings.
Mr. Farhan Raza
This CME programme
was conducted by Mr. Farhan Product Manager in Atco Laboratories
which had sponsored this meeting. Atco Laboratories, it may be
mentioned here is sponsoring all CME programmes of Pakistan Aspirin
Foundation for the last many years. Atco has also produced a highly
informative Booklet on Aspirin in Urdu which is being distributed
among the healthcare professionals and public all over the country.
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Aspirin Update Seminar at Sargodha
Patients with more than 10%
absolute ten years risk of CAD
should be put on low dose Aspirin therapy - Prof. Akbar Chaudhry
Despite lot of data showing safety and
efficacy of Aspirin in prevention of CAD and Stroke, this mother
anti-platelet agent still remains under used |
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From our correspondent
SARGODHA: Pakistan Aspirin Foundation in collaboration with Pakistan
Medical Association Sargodha organized a seminar on Aspirin Update
here on October 20th 2010. It was chaired by Prof. M. Siddique a
noted physician and it was very well attended by members of the
medical profession. Prof. M.Akbar Chaudhry FRCP Principal
Continental Medical College Lahore who is also President of Pakistan
Aspirin Foundation in his presentation discussed in detail the well
established indications of Aspirin therapy. He was of the view that
despite lot of data showing its safety and efficacy in prevention of
CAD and Stroke, this mother anti-platelet agent was still under used
all over the world including Pakistan. This is one of the reasons
that Pakistan Aspirin Foundation has started this CME programme for
healthcare professionals to update them and promote the use of
Aspirin to help the patients.
Pakistan Aspirin Foundation organized a seminar
on Aspirin at Sargodha in collaboration with the local PMA.
Picture taken on the occasion shows on left Mr. Akhtar General
Manager Marketing of Atco which had sponsored this CME
programme presenting a flower bouquet to one of the
distinguished paraticipants while President of Sargodha PMA
Dr.Sikandar Hayat Warriach is also seen in the center. Also
seen in the picture are Mr. Shaukat Ali Jawaid, Mr. Akhtar,
Prof. Akbar Chaudhry, and Dr. Niazi.
Aspirin, he said was now one hundred ten
years old drug. Speaking about its well established indications he
mentioned Acute Myocardial Infarction, Acute coronary Syndrome,
Secondary prevention of AMI, Primary prevention of CAD, Acute
Ischemic Strokes, Transient Ischemic Attacks (TIAs), primary and
secondary prevention of stroke, hypertension, diabetes mellitus
besides prophylaxis against Deep Vein Thrombosis and Pulmonary
Embolism. In addition it has numerous emerging indications which
include colorectal cancer, esophageal and gastric cancer, prostate
cancer, pre eclampsia, Alzheimer’s disease, insulin resistance etc.
This most economically priced and easily available anti-platelet
agent which has life saving properties has proved to be a miracle
drug which is also called as Poor Man’s Statin.
Field force representatives of
Atco laboratories photographed along with Prof. Siddique,
Prof. Akbar Chaudhry and Dr. Mushtaq Cheema during the Aspirin
seminar held at Sargodha on October 20th 2010
He
advised the healthcare professionals that any patient who complains
of chest pain should be asked to immediately chew 325mg tablet of
Aspirin or use soluble Aspirin before taking him to any doctor or
healthcare facility as it could prove life saving. We should keep
Aspirin with us all the time, in emergency bag, at clinic and at
home as we may need it any time. In case of Acute Myocardial
Infarction if used within six hours, it reduces mortality by about
23% and if it is used along with streptokinase, the risk reduction
could be 45%. It can be used in combination with clopidogrel which
will further reduce the risk but one has to be careful of increased
side effects. All CCU patients on discharge must be prescribed Low
Dose Aspirin therapy 75mg daily unless there is some contra
indication. Those who are allergic to Aspirin can be put on other
ant platelet agents.
In case of stroke, Aspirin 150-300mg daily should be initiated as
early as possible and then continued indefinitely. In high risk
patients it can be combined with Dipyridamol or Ticlodipine or
Clopidogrel. Studies have shown relative risk reduction of stroke
and death with Aspirin by 31% as compared with placebo and there is
minimal risk of bleeding. Relative risk reduction of secondary
ischemic stroke, TIAs and death is 27% with Aspirin. There is
evidence that continuous low dose Aspirin therapy reduces risk of
colorectal cancer by 40-50%, esophageal cancer risk reduction is
reported as 90% while gastric cancer reduction is reported 48% in
male and 52% in female. There are reports that Aspirin can reduce
prostate cancer risk by 50%.
He thanked Dr. Maqbool H. Jafary the former President of Pakistan
Aspirin Foundation who had collected most of this data and called
upon the healthcare professionals to ensure that all those who need
to be on Low Dose Aspirin therapy are not deprived of the benefits
of this miracle drug. Enteric coated Aspirin tablets are safe for
long term use that is why it is preferred. Replying to questions
from the audience Prof. Akbar Chaudhry said that Aspirin should be
stopped at least seven to ten days before elective surgery and in
case of emergency surgery, patients on Aspirin therapy may require
plasma transfusion. In pregnancy it is only indicated in pre-eclampsia
in women with poor obstetric history.
Prof. M. Siddique commended the presentation and remarked that at
home Aspirin should be kept away from children.
Mr. Shaukat Ali Jawaid General Secretary of Pakistan Aspirin
Foundation talked about the aims and objectives of the Foundation
and also highlighted some of its achievements so far. He thanked
Atco Laboratories for sponsoring CME activities of the Foundation
for the last many years but hastened to add that keeping up the
professional ethics, we do not promote and patronize any particular
brand of Aspirin, he added. Earlier Dr.Sikandar Hayat Warraich
President of Sargodha PMA welcomed Prof. Akbar Chaudhry,
participants and also thanked Pakistan Aspirin Foundation for
organizing this academic activity. He suggested that a public
awareness session on Aspirin should also be organized which will be
quite informative and useful.
The meeting was conducted by Mr. Farhan Raza Product Manager in Atco
Laboratories which had sponsored this meeting.
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Antiplatelet therapy has a role in
prevention of
cardiovascular diseases - Dr. Maqbool H.
Jafary
Regular use of Low Dose Aspirin
reduces the risk of unstable angina by 46%, stable angina by 33%,
peripheral arterial disease by 23% and in patients undergoing
angioplasty by 53% -
Prof. Akbar Chaudhry
Aspirin is considered as poor man’s Statin
- Prof. Feroze Memon |
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KARACHI: Prof. Feroze
Memon Prof.of Cardiology at Isra University Hyderabad along with
Prof. Naeem Aslam Prof. of Cardiology at Sheikh Zayed Medical
College Rahim Yar Khan chaired the Breakfast session on Antiplatelet
Therapy during the KIHD 3rd annual symposium. The session held at
the KIHD campus on May 1st 2010 was very well attended. The panel of
experts included Prof. Akbar Chaudhry President of Pakistan Aspirin
Foundation and Dr. Maqbool H. Jafary. Also present were Prof. Wahid
Sahibzada from Peshawar, Dr. Masood Ahmad from Ittefaq Hospital
Lahore, Prof. S.H. Shafqat and Dr. A. Rashid Khan besides many
family physicians.
In his introductory remarks Prof. Feroze Memon said Aspirin is
considered as poor man’s Statin. It is economically priced and is
easily available. Hence its use need to be promoted in its well
established indications.
KIHD’s third annual symposium started with a breakfast session
on Anti Platelet therapy with special reference to safety and
efficacy of low dose Aspirin sponsored by Atco Labs. Group
photograph taken on the occasion shows some eminent cardiologist
of Pakistan from (L t o R) Prof. SH Shafaqt, Dr. Masood, Prof.
Naeem Aslam, Mr. Farhan Raza (Product Manager Atco), Prof.
Feroze Memon, Prof. Ishaq, Prof. Akbar Chaudry, Mr. Shaukat Ali
Jawaid (Chief Editor PULSE), Prof. Hafiz Chaudry, Prof. Wahid
Sahibzada who participated in the discussion. Mr. Zia and Dr.
Faisal from Atco Labs are also seen on extreme left and extreme
right.
Prof. Akbar Chaudhry
Principal Continental Medical College in his brief presentation
highlighted the safety and efficacy of antiplatelet therapy in
reducing morbidity and mortality in cardiovascular diseases. He was
of the view that CAD has now become an epidemic in Pakistan. Use of
Aspirin therapy he said is recommended for all apparently healthy
individuals at high risk of CVD. AHA recommends it for primary
prevention of first mi which is reduced by one third and one sixth
reduction in vascular events. Similarly in secondary prevention
myocardial infarction risk is reduced by one third, stroke by a
quarter and CVD death by one sixth. Enteric coated aspirin he said
is preferred as it is safe and there is no risk of gastric
irritation. Low dose aspirin therapy is extremely safe and effective
but those who are resistant or allergic to Aspirin, should be put on
other antiplatelet agents.
Dr. Maqbool H. Jafary in his remarks said that emphasis should
always be on preventive aspects. Anti platelets have a role in
prevention of cardiovascular diseases? Participating in the
discussion Prof. M. Ishaq said that Aspirin remains under utilized.
It is economical priced and Pakistan Aspirin Foundaiton also needs
to revise its guidelines which were earlier revised couple of years
ago. AAUS study conducted by Pakistan Aspirin Foundation had
revealed very low use of Aspirin by Family Physicians as well as in
CCU when the patients were being discharged but due to CME
activities by the PAF, now use of Aspirin has considerably improved
among the family physicians as well. Prof.Feroze Memon felt that
since it is the junior doctors who prepare the discharge slips in
the CCU, they should be educated not to forget aspirin in the
prescription. There are very few contra indications for the use of
Aspirin and the important one are active peptic ulcer disease but it
must be ensured that diagnosis of PU are correct and one should not
confuse it with Gas, and heartburn etc which is quite common.
Persantin it was said is not superior to aspirin therapy. Persantin
is used quite frequently in stroke patients as well as in TIAs. In
fact it is the combination of Aspirin and Persantin which is
considered more effective in these Stroke and TIA patients. Prof.
S.H. Shafqat opined that as the awareness about the use of Aspirin
goes up, hopefully more and more patients will benefit. It remains
under use and family physicians in particular must promote its use,
he remarked. Dr. Maqbool H.Jafary opined that we need to conduct
another study to find out the benefits of our CME programmes which
have been going on now for many years wherein a large number of
Family Physicians have been participating. Prof. Naeem Aslam
remarked that all Type-2 diabetics must be put on low dose Aspirin
therapy on regular basis and the recommended dose is 150mg of
enteric coated tablets. Dr. Masood consultant cardiologist from
Ittefaq Hospital Lahore felt that except patients with gastric
symptoms, Aspirin can be safely prescribed to CAD, ACS patients. Dr.
A Rashid Khan from Abbasi Shaheed Hospital said that regular use of
low dose Aspirin reduces morbidity and mortality in cardiovascular
diseases significantly. It added advantage is that it is
economically priced and its availability is not problem even in
small towns and cities.
Responding to another question Prof. Akbar Chaudhry said that in
case of major surgery, Aspirin therapy should be stopped at least
ten days before surgery but in case of minor surgery, even five days
stoppage of aspirin therapy is good enough. This meeting was
sponsored by M/s Atco laboratories as a part of their CME programme
to keep the healthcare professionals update on the use of Aspirin
therapy. Atco Laboratories has also played a vital role in promoting
the use of Aspirin in Pakistan sponsoring all the academic
activities of Pakistan Aspirin Foundation for the last many years.
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Aspirin Update
Seminar at Okara
In primary prevention Aspirin
reduces the risk of first MI
by 33%, risk of first stroke by 25% and the risk of
CVD death by about 17% -
Prof. Akbar Chaudhry
Usage of Low Dose Aspirin has
increased but
still we need to do a lot more
Family Physicians and GPs can play a vital
role in promoting
the use of LDA which can also save many precious lives in AMI |
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From our correspondent
OKARA: Pakistan Aspirin Foundation in its Continuing Medical
Education programme to promote the use of Aspirin in its well
established indications organized a seminar on Aspirin Update in
collaboration with Pakistan Medical Association Okara on April 8th
2010. The meeting held at the local PMA house was very well attended
by members of the PMA. Prof. M. Akbar Chaudhry a noted physician and
President of Pakistan Aspirin Foundation who is currently Principal
of Continental Medical College Lahore was the main guest speaker.
Prof. M. Akbar Chaudhry and
Mr. Shaukat Ali Jawaid President and General Secretary
respectively of Pakistan Aspirin Foundation photographed
along with office bearers of PMA Okara and some other
guests during the seminar on Aspirin Update held at Okara
on April 8th 2010
In
his presentation Prof. Akbar Chaudhry highlighted the safety and
efficacy of Aspirin therapy in coronary artery disease particularly
Acute Coronary Syndromes and said that one tablet of soluble Aspirin
or four tablet of enteric coated Aspirin chewed immediately after
chest pain can prove to be life saving. Most often the heart attacks
occur late at night or early in the morning hours when it is not
possible to find a doctor or reaching the healthcare facility may
also take some time. Hence, if Aspirin is readily available, the
patient should be advised to immediately take Aspirin tablet and
then efforts should be made to shift the patient to a hospital. It
was also pointed out that recent meta analysis in Cochran Review has
revealed that regular use of low dose Aspirin should be preferred at
night which can take care of early morning episode in case of blood
pressure peaks.
Pakistan Aspirin Foundation in collaboration
with PMA Okara organized a seminar on Aspirin Update at the
local PMA House on April 8th. Photograph taken on
the occasion shows Prof. M.Akbar Chaudhry President of PAF
along with some members of PMA and executives and field
force representatives of Atco Laboratories which had
sponsored this meeting.
American Heart Association has
recommended regular use of low dose aspirin for all apparently
healthy individuals who are at risk of cardiovascular diseases. In
random trials and Meta analysis, it has been shown that Aspirin
significantly reduces the risk of cardiovascular diseases. As
regards primary prevention, it reduces first MI by about one third
and all important vascular events by one sixth. In secondary
prevention, MI is reduced by one third and stroke by about a quarter
and cardiovascular death by one sixth. Speaking about the guidelines
for primary prevention of CVD Prof. Akbar Chaudhry said that one
should begin risk factor assessment in adults at the age of twenty
years. All adults over the age of forty years should know their
absolute risk of developing CVD. Risk intervention strategies
include smoking cessation, physical activity, diet therapy, weight
control, blood pressure control, lipid control, diabetes control and
Aspirin therapy.
Prof. Akbar Chaudhry President
Pakistan Aspirin Foundation and Principal Continental
Medical College presenting flower bouquet to Dr. Abdul
Aleem Asif and Dr. Zaeemuddin Abid consultant physicians
in Okara at the Aspirin Update seminar held in Okara on
April 8th 2010.
Speaking about the benefits of Aspirin, Prof. Akbar Chaudhry said
that in primary prevention it reduces the risk of first MI by 33%,
reduces the risk of first stroke by 25% and the risk of CVD death by
about 17%. In secondary prevention, the chances of serious vascular
events are reduced by 46% in unstable angina, 33% in stable angina,
23% in peripheral arterial disease and 53% in patients undergoing
angioplasty. Despite all these findings, it is a pity that Aspirin
remains under used. Referring to the Aspirin Awareness and Usage
Study (AAUS) conducted by Pakistan Aspirin Foundation couple of
years ago at seventeen CCUs all over Pakistan which enrolled over
fourteen hundred ACS patients, Prof. Akbar Chaudhry said that only
16% of patients got aspirin at home when they suffered from chest
pain. Again only 20.8% of these patients were prescribed Aspirin by
their family physicians and what is more tragic is the fact that
only 50% of these patients were prescribed Aspirin on discharge. It
is because most often the discharge slips are prepared by junior
house offices who need to be educated as most of them do not realize
the importance of Aspirin therapy. However, Prof. Akbar Chaudhry
further stated that this study was conducted many years ago. Since
then Pakistan Aspirin Foundation has been conducting its CME
activities all over the country and this has increased the usage of
Aspirin therapy to a great extent though we still need to do a lot
to promote the regular use of low dose Aspirin in its established
indications.
Prof. Akbar Chaudhry’s views were further confirmed when taking part
in the discussion Dr. Zaeemuddin Abid consultant physician pointed
out that he has started using Aspirin in his patients. Whenever the
patient with ACS comes, he immediately asks him to take two tablets
of Aspirin. First their blood pressure is controlled and then they
are put on regular use of Low Dose Aspirin therapy. Once he saw a
patient who died the next morning due to acute myocardial
infarction. Since then, as a practice he makes sure that all these
patients are given aspirin immediately when they consult him and it
also convinces the patients of the importance of Aspirin therapy.
Members of Sales team of Atco
Laboratories photographed along with Mr. Akhtar Tahir
Business Unit Head and Mr. Farhan Raza Product Manager
Atco Laboratories during a seminar on Aspirin Update held
at Okara recently.
Dr.
Abdul Aleem another consultant physician of Okara pointed out that
Aspirin is extremely safe and effective in ACS. In his clinical
practice he has found Aspirin highly beneficial in acute coronary
syndrome. He advised his patients to immediately take Aspirin tablet
in case of chest pain irrespective of the fact whether it is cardiac
in nature or not but those who do not tolerate Aspirin they are
advised not to take it. Similarly in acute gastric bleeding,
patients are advised not to take Aspirin. He advised the family
physicians to use enteric coated Aspirin which is much safer. Dr.
Aleem further stated that in secondary prevention of CAD, Aspirin
should be used without any hesitation unless it is contra indicated.
However, he re-emphasized that one must first control blood pressure
before putting patient on low dose aspirin therapy. In elderly
patients with gout, urine analysis and keratinine should be checked
regularly. Aspirin, Dr. Aleem said is very economically priced
wonder drug and affordability is not a problem. It should be used
more and more. Family Physicians should encourage its usage. All
doctors over the age of fifty years, he said, must use low dose
aspirin regularly.
Mr.
Shaukat Ali Jawaid General Secretary Pakistan Aspirin Foundation
highlighted the objectives and accomplishments of the Foundation so
far. Referring to the use of Aspirin therapy in primary prevention
of CAD, he stated that though lot of evidence is available but the
largest trial which will enroll over twelve thousand patients in
five countries including USA, UK, Germany and China has commenced in
2009 and it will last for four years. The results of this ARRIVE
study will be available in 2013 which will further confirm the
efficacy of regular use of low dose Aspirin therapy in primary
prevention of CAD. He also referred to the publication of Book on
Aspirin- the wonder life saving drug, an Urdu Booklet on Aspirin,
revision of consensus report on use of Aspirin in various diseases
which gives details about the dosage, indications and contra
indications etc. This report is also accessible on the website of
Pakistan Aspirin Foundation (www.pakaspirin.org) and it is being
freely distributed throughout the country. Both Prof. Akbar Chaudhry
and Mr. Shaukat Ali Jawaid made it clear that though they are
thankful to M/s Atco Laboratories and its team headed by Mr. Akhtar
and Mr. Farhan Raza for helping Pakistan Aspirin Foundation in its
academic activities but upholding professional ethics, they do not
support any particular brand of Aspirin. It is up to the physicians
to prescribe the drug of their choice based on their clinical
experience and trust.
Later Dr. Liaquat Ali took up the issue of violence against doctors
and asked the doctors community to have unity among their ranks. He
also talked to the SHO and other officials of the district
administration urging them to arrest the culprits who misbehaved
with doctors on duty at the local DHQ Hospitals a few days ago
otherwise they will march to their offices to stage a sit in and
record their protest.
The programme was conducted by Dr. Nasir Mahmood General Secretary
of the local PMA while Dr. Ishtiaq Ali President of PMA also briefly
spoke on the occasion. Later flower bouquet was presented to the
guest speakers and others. The meeting as usual was sponsored by
Atco Laboratories for which Mr. Farhan Raza and his team from Atco
laboratories had been quite busy. Mr. Akhtar Business Unit Head in
Atco laboratories was also present on this occasion.
The PMA Okara needs to be commended to have established its own
purpose built PMA House which is being used for holding all such
academic activities. The PMA Okara it is learnt is quite active and
its successive leadership has been quite busy in not only holding
CME programmes from time to time but also safeguarding the interests
of the doctor’s community. During the recent violence against the
doctors, the PMA has played a vital role to ensure that their
viewpoint is heard by the administration and necessary steps are
taken so that doctors can work with devotion without any fears about
their security.
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Aspirin Update seminar at
Kasur
Regular use of low dose
Aspirin reduces morbidity
and mortality in CAD -
Prof. Akbar Chaudhry
All Type-2 diabetics should be
put on Aspirin therapy
if there is no contra indication -
Prof. Mahmood Ali Malik |
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KASUR: Pakistan Aspirin Foundation in collaboration with the PMA
Kasur organized a seminar on An Update on Aspirin here on April 7th
2010. Prof. Mahmood Ali Malik a noted physician and former Principal
of King Edward Medical College and Prof. M. Akbar Chaudhry President
of Pakistan Aspirin Foundation currently Principal of Continental
Medical College Lahore were the two guest speakers. The meeting was
very well attended by members of the PMA which included GPs and
Family Physicians as well.
Pakistan Aspirin Foundation in
collaboration with PMA Kasur organized a seminar Update on
Aspirin at Kasur on April 7th. Picture sows Dr. Safdar one
of the senior most physicians presenting flower bouquet to
Prof.M. Akbar Chaudhry President of the Foundation.
In
his presentation Prof. Akbar Chaudhry said that Aspirin which has
now completed over one hundred ten years of its use in clinical
medicine was a wonder drug of the century. Despite numerous studies
which have proved that continued use of low dose Aspirin reduces the
morbidity and mortality to a great extent, it remains underused. Its
established indications include Acute Myocardial Infarction, Acute
Coronary Syndrome, secondary prevention of MI, primary prevention of
CAD, TIAs and Stroke, prophylaxis for thromboembolism, DVT,
Hypertension and Diabetes. In addition there are many emerging new
indications like cancer, prostate cancer, Alzheimer’s disease, Pre-eclampsia,
renal diseases, insulin resistance, etc., which continues to amaze
the research scientists.
Prof. Mahmood Ali Malik, Prof.
Akbar Chaudhry, Dr. Ghulam Shabbir Yazdani, Dr. Inayat,
Mr. Akhtar Business Unit Head of Atco and others
photographed after the seminar on Aspirin held at Kasur
recently.
He
also gave a brief historical background to the discovery of Aspirin
and the story starts from 1948 but it was the pioneering study of
Scottish Physician Dr.Peter Elwood who first showed in 1974 that
Aspirin prevents heart attacks. Since then its anti-platelet
activities have been highlighted in various disorders. In case of
acute myocardial infarction, one full tablet of Aspirin or use
soluble Aspirin immediately which will reduce the chances of any
fatal event by almost 25%. According to reports over forty thousand
tones and one hundred billion tablets of Aspirin are used every year
all over the world. Its popular uses include cardiovascular
diseases, arthritis, headaches, etc. As regards its use in primary
prevention of cardiovascular diseases, studies have shown that it
reduces non-fatal MI by 32%, non-fatal stroke by 18% and total
cardiovascular mortality is reduced by 13% besides it also reduces
important vascular events by 13%. It reduces strokes in women much
more than men.
Continuing Prof. Akbar Chaudhry said that if the absolute ten years
risk is less then six percent, there is no need for aspirin but if
it is between 7-14%, it should be left to the patient’s preference.
However, if the absolute ten years risk is more than 15%, these
patients must be put on Aspirin therapy. In secondary prevention of
cardiovascular diseases, Aspirin reduces non-fatal MI by 32%,
non-fatal stroke by 27% and total CV mortality by 15% and important
vascular events by 25%.
Pakistan Aspirin Foundation in
collaboration with PMA Kasur organized a seminar on Aspirin Update
at Kasur on April 7th which was very well attended. Picture shows
Prof. Akbar Chaudhry, Prof. Mahmood Ali Malik, Mr. Shaukat Ali
Jawaid, Dr. Ghulam Shabbir Yazdani, Dr. Aslam Randhawa and Dr.
Inayatullah speaking at the occasion.
As
regards use of Aspirin in stroke, Meta analysis of six studies which
enrolled 51, 342 women and 44,112 men the reduction in stroke in
women was 17% as compared to men which was 14%. Evidence is also
accumulating regarding the use of low dose aspirin in primary
prevention of stroke. In case of acute ischaemic stroke, the patient
should be given 150-300mg of Aspirin within forty eight hours as it
is the drug of choice. Aspirin reduces the risk of early death as
well as recurrence of stroke. SALT study regarding secondary
ischaemic stroke has demonstrated that relative risk reduction of
stroke and death with Aspirin vs. placebo is 31% with minimal risk
of bleeding. Again relative risk reduction of TIA and death is 27%
with Aspirin therapy. Regular use of low dose Aspirin also helps in
prevention of secondary stroke. Various studies have confirmed that
Aspirin remains underused in stroke, TIAs, CAD. Hence these patients
should be encouraged to use Aspirin for secondary prevention
especially in the high risk patients.
Prof. Akbar Chaudhry also refereed to AAUS study conducted by
Pakistan Aspirin Foundation which involved over fourteen hundred ACS
patients in 17 CCUs all over Pakistan. It showed that only 16%
patients got Aspirin at home, only 20% patients were advised use of
Aspirin by GPs while in ER 60% patients got Aspirin and in Ward
about 71% patients got Aspirin. What was more surprising was the
fact that at discharge only 50% of these patients were prescribed
Aspirin. Prof. Akbar Chaudhry remarked that since most often the
discharge slip is prepared by junior doctors, they do not give too
much importance to Aspirin. However, ever since we started this
awareness campaign, the situation has improved and now the use of
Aspirin in its well established indications is increasing. However,
there is still lot to be done as regards education of the GPs,
Family Physicians, other healthcare professionals as well as the
patients. He concluded his presentation by stating that every doctor
must keep Aspirin with him, at the clinic as they may need it any
time and it might prove life saving. They should also educate the
patients that in case of chest pain irrespective of the fact whether
it is cardiac or non cardiac, they must immediately chew a full
tablet of Aspirin of 325mg or use soluble Aspirin. Combination
therapy of Aspirin plus clopidogril further reduces the relative
risk by 20%. In patients who are sensitive to Aspirin therapy, other
anti platelet agents should be used. Enteric coated Aspirin is
preferred as it eliminates the chances of any gastric irritation.
Prof. Akbar Chaudhry acknowledged Dr. Maqbool H. Jafary the former
President of PAF who he said has made a major contribution to this
presentation.
Dr. Aslam Randhawa EDO Health Kasur
and Dr. Iqbal Mayo President PMA Kasur presenting bouquet to
Prof. Mahmood Ali Malik and Mr.Shaukt Ali Jawaid at the Aspirin
seminar held here on April 7th 2010
Prof. Mahmood Ali Malik in his brief presentation advised the
participants to control blood sugar and blood pressure of their
patients. In diabetics a BP level of 120/80 is desirable but 130/85
is also acceptable. Make sure that the HbA1c is less than six which
is preferred. Fasting blood sugar should be less than one hundred
which must be aimed at. All Type-2 diabetics in high risk group must
be put on regular low dose Aspirin therapy. However, young patients,
with no history of cardiovascular disease, no TIA, no family
history, non-smokers will not require Aspirin therapy. In known
ulcer patients, Aspirin is avoided because of risk of bleeding.
However, in case of emergency if need be, one tablet of Aspirin
could be use in AMI just once as it might prove life saving.
Dr. Aslam Randhawa EDO Health speaking at the occasion said that
Aspirin is very economically priced drug which is easily available
and affordable. He thanked the speakers for their valuable advice
and felt that many a time’s doctors in rural areas with not many
facilities can save many precious lives by just administering
Aspirin therapy to AMI patients.
Dr. Iqbal Mayo President of local PMA and Dr. Inayatullah Sheikh GS
of PMA also briefly addressed the meeting and thanked the speakers
and Atco Laboratories for sponsoring this academic activity. Dr.
Ghulam Shabbir Yazdani consultant cardiologist at DHQ Hospital Kasur
welcomed the guest speakers.
Earlier Mr. Shaukat Ali Jawaid General Secretary of Pakistan Aspirin
Foundation highlighted the history and accomplishments of the
Foundation. He as well as Prof.Akbar Chaudhry both emphasized that
the Foundation does not promote any particular brand of Aspirin and
it is up to the physicians to decide. Keeping up the professional
ethics we just promote the use of Aspirin. However, we are grateful
to M/s Atco Laboratories who have been sponsoring our CME programmes
all over the country for the last many years. They specially thanked
Mr. Akhtar Business Unit Head and Mr. Farhan Raza Product Manager
from Atco Laboratories for organizing these meetings in far flung
areas all over Pakistan on regular basis to update the healthcare
professionals on safety, efficacy and use of Aspirin therapy. Copies
of Consensus Statement on Guidelines for the use of Aspirin as well
as an Urdu Booklet on Aspirin was also distributed among the
participants.
Prof. Mahmood Ali Malik, Prof. Akbar Chaudhry and Mr. Shaukat Ali
Jawaid also visited the DHQ Hospital Kasur where they were welcomed
by Dr. Ghulam Shabbir Yazdani. They also met the MS of the hospital
and visited various sections of the hospital. During the visit to
the CCU and cardiology ward, Dr. Yazdani informed that during the
last three months they had received about fifty patients of AMI and
most of them were quite young. Thrombolysis therapy is available
free. The 120-Bed DHQ Hospital has 32-bed cardiology ward. Senior
staff at the hospital includes physician, surgeon, cardiologist,
obstetrician and gynaecologist besides pediatrician. Lot of
development activity is going on to improve and upgrade the
facilities available at the hospital. A few more residences for
senior doctors are also being constructed.
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More efforts are
needed to create awareness
about the use of Aspirin -
Nisar Khuro
Over use of antibiotics and over dosing
of drugs must be
checked as it results in serious adverse effects |
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From our correspondent
LARKANA: Inaugurating the 5th National Conference of Pakistan Aspirin
Foundation held here at the Chandka Medical College, Mr. Nisar Khuro
Speaker of the Sindh Assembly has emphasized the need to create
awareness among public as well as the healthcare professionals about the
use of Aspirin which is quite safe and effective besides being
economically priced drug. He also advised the healthcare professionals
to check the over use of antibiotics and avoid overdosing of drugs as
they all lead to serious adverse effects thereby increasing morbidity.
Mr.Ayaz Soomro Sindh Minister for
Law presenting a shield to Prof. Mahmood Ali Malik former
Principal KEMC and founder President of Pakistan Aspirin
Foundation at the public awareness session on Aspirin
organized by Pakistan Aspirin Foundation at SMBBMU/CMC Larkana
on October 31st. Prof. Saeed Ahmad Sangi and Prof. Akbar
Chaudhry are also seen in the picture.
Quality of the drugs being made available
was another issue which needs to be looked into.
He further stated that we all need to overcome our weaknesses and
be loyal to the Nation. By overusing the drugs particularly the
antibiotics, we will not be serving the ailing humanity. He suggested
promoting rational use of drugs and antimicrobial agents and keeping the
healthcare professionals informed on such issues. He also referred to a
recent resolution passed by the Sindh Assembly wherein it was suggested
that all couples before getting married must be examined and tested for
Thalassaemia major, Hepatitis B & C and AIDs. The doctors should also
prescribe cost effective medications which are affordable by the people.
Over use of antibiotics often leads to kidney failure and other serious
diseases which all can be checked and prevented by ensuring ethical
practice.
Health and Education Mr. Nisar Khuro said are some of the basic issues
and the government was trying to give them due importance and priority.
He hoped that with democratic era the country will eventually find
peace, overcome terrorism, and ensure economic development. Once the
under construction roads are completed, we will have more flights and
bigger planes coming to Mohenjo Daro airport and Larkana will get its
recognition which it deserves. Nothing is impossible and we all can make
everything possible by working together, he remarked.
Mr. Nisar
Khuro Speaker Sindh Assembly was the chief guest at the national
conference of Pakistan Aspirin Foundation held at SMBBMU/Chandka
Medical College Larkana on October 31st 2009. Picture shows Mr.
Nisar Khuro, Prof. Sikandar Sheikh VC SMBBMU, Prof.Mahmood
Ali Malik, Dr. Maqbool H. Jafary, Prof.Javed Akram, Prof. Zaman
Sheikh, Prof. Saeed Ahmad Sangi and Dr. Abdul Majeed speaking in the
inaugural session.
Prof. Sikandar Sheikh Vice Chancellor of
Shaheed Mohtarma Benazir Bhutto Medical University in his address at the
occasion said that SMBBMUJ got its charger on October 18th 2008 and it
formally started functioning on July 9th 2009. Its constituent
institutions include Chandka Medical College, Sardar Ghulam Mohammad
Maher Medical College, Chandka Dental College which was being
established, and Chambat Institute of Medical Sciences. We have short
term and long term goals for the development of this university. We are
shortly sending fifteen to twenty young doctors for higher training
leading to PhD in different basic sciences and by the time they return,
we will have fully developed basic sciences departments and
laboratories. Three to four new buildings are being constructed while a
500-bed state of the art teaching hospital will be part of the
University which will provide the most modern teaching, training and
diagnostic facilities. Refresher courses for the faculty members are
also being organized under faculty development programme. Departments of
plastic surgery, thoracic surgery and hepatology will soon be
established. He thanked Pakistan Aspirin Foundation for selecting SMBBMU/CMC
as a venue for their national conference. Such academic activities also
help improve CPD of the participants thereby helping improve the patient
care, he added.
Dr. Maqbool H. Jafary President of Pakistan Aspirin Foundation in his
presidential address highlighted the safety and efficacy of Aspirin
which is the most economically priced drug. This life saving miracle
drug continues to surprise us all as its new and emerging indications
keep on increasing every day. Lot of research is going on these days. In
particular it is its antiplatelet effects which has helped save many
patients suffering from acute myocardial infarction, Acute Coronary
Syndrome and helped reduce morbidity from cardiovascular and
cerebrovascular diseases.
Mr. Ayaz Soomro Sindh Minister for Law was
the chief guest at the public awareness session organized by Pakistan
Aspirin Foundation during its national conference at SMBBMU/Chandka
Medical College Larkana on October 31st 2009. Picture shows him
presenting conference shields to (from L to R) Prof. Sikandar Sheikh,
Prof. Akbar Chaudhry, Dr.Maqbool H.Jafary, Prof. Talat Naheed and
Prof. Khalida Soomro.
Dr. Saeed Sangi Prof.of Cardiology at
Chandka Medical College convener of the conference welcomed the guests
and participants to the conference. He also thanked the chief guest for
gracing the occasion and Vice Chancellor, Principal and faculty members
of SMBBMU, CMC for their cooperation. He thanked the delegates and
participants particularly from Karachi and Lahore who made it possible
to attend and make presentations in the conference.
One of the scientific sessions during the conference was chaired by
Prof. Wazeer Sheikh former Principal of CMC and Councilor of CPSP while
another session was chaired by Prof. Abrar Ahmad Shaikh Dean Faculty of
Medicine at SMBBMU. Prof. M. Akbar Chaudhry chaired the third scientific
session. An important highlight of the conference was participation of
fifteen former and current Principals of various medical colleges. A
number of faculty members from CMC and guests from Lahore and Karachi
were members of the Experts Panel in different sessions.
Mr. Shaukat Ali Jawaid General Secretary of Pakistan Aspirin Foundation
introduced the guest speakers besides highlighting the aims and
objectives of the Foundation and its accomplishments so far. Later
conference mementoes in the form of shields were presented to the chief
guest, VC SMBBMU, Principal CMC, Mr. Munawar Abbasi the local MPA and
members of the organizing committee. The traditional Sindhi Ajrak and
Cap were presented to all the guest speakers, Patron, Convener and
members’ of the organizing committee. The meeting started late and time
management could not be improved despite best efforts. Hence no time was
left for discussion after the presentations which is so essential.
However, the organizers did provide time for discussion on all the
presentations at the end of the third scientific session.
Dr. Saeed Sangi hosted a dinner at his residence on Friday October 30th
which was largely attended by guests from Karachi and Lahore besides
faculty members and Vice chancellor of SMBBMU, CMC and elite of the
city. Apart from Atco Laboratories who not only arranged travel of the
speakers and their stay besides hosting lunch on October 31st during the
conference and making excellent transport arrangements, M/s PharmEvo
arranged the conference backdrop and shields. M/s Himont organized the
registration desk while a few selected companies participated in the
exhibition. Their contributions were recognized by the organizers at the
public awareness session held before dinner and they were presented
conference mementoes.
Scientific Sessions
Prof. Wazeer Sheikh former Principal Chandka
Medical College along with panel of experts chaired the first scientific
session. Mr. Shaukat Mutakee consultant pharmacist was the first speaker
who talked about mode of action of Aspirin and other antiplatlet agents
besides mentioning the side effects profile. He also pointed out that
these days 81mg tablet instead of 75mg tablet is being used which is
considered much better. Aspirin’s duration of action, he said, is four
to six hours and its elimination half life is 4.7 to 9 hours. It does
have interaction with other drugs and certain foods and so far the
aspirin resistance has been reported in 5.5% of cases.
Mr. Farhan Raza Product Manager
Atco Laboratories, Mr.Shaukat Ali Jawaid, Prof. Akbar Chaudhry,
Dr. Maqbool H. Jafary, Prof. Saeed Ahmad Sangi, Prof. Mahmood
Ali Malik, Prof. Khalida Soomro and others photographed during
the national conference of Pakistan Aspirin Foundation at
Chandka Medical College Larkana on October 31st 2009.
Prof. Javed Akram Principal Allama Iqbal
Medical College highlighted the cost effectiveness of Aspirin therapy.
Aspirin, Prof. Javed Akram opined, is a time tested drug. Even otherwise
old is always considered Gold. Effectiveness of a drug is measured in
various forms i.e. can it cure the disease, can it reduce the majority
of the symptoms, safety of the drug also plays a vital role in efficacy
and effectiveness. He also referred to various drugs like coxibs and
other NSAIDs which had to be withdrawn later on due to their serious
side effects. Similarly Hormone Replacement Therapy had to be withdrawn
but Aspirin remains in the market and is in clinical use for over
hundred years and its indications are increasing with the every passing
day. Aspirin is far more effective and better tolerable than clopidogrel
which can be effectively used in combination with Aspirin in various
conditions. Various studies have shown that Aspirin is the most
effective drug in Acute Coronary Syndromes and Acute Myocardial
Infarction in particular; stroke and TIAs, secondary prevention of
hypertension and stroke but it must be used as per its established
protocol. He advised the physicians not to be afraid of simple things.
Had Aspirin been a more expensive drug, more healthcare professionals
would have been using this, he remarked.
Dr. Maqbool H. Jafary President of Pakistan Aspirin Foundation
highlighted the efficacy of combination of Aspirin with Clopidogrel
which leads to 20% further risk reduction in AMI. However, this
combination should be avoided in primary prevention of cardiovascular
events. But this combination can be used in ACS without stents, with
bare metal stents, drug eluting stents but not in stroke. Dr. Jawaid
Akbar Sial from Chandka Medical College spoke about non-invasive role of
GPIIb/IIIa.
Prof. Abrar Sheikh Dean Faculty of Medicine at SMBBMU along with panel
of experts chaired the next session. Prof. Zaman Sheikh Prof. of
Medicine at DUHS and Executive Director of National Institute of
Diabetes and Endocrinology in DUHS spoke about the use of Aspirin in
diabetes. He opined that all Type-2 diabetics who are at risk of
developing cardiovascular diseases must be put on low dose aspirin
therapy. Enteric coated tablet of 75mg is as effective as high dose.
Similarly low dose Aspirin therapy should also be prescribed to high
risk individuals over the age of forty years, he remarked.
Prof. Mahmood Ali Malik an eminent physician and former Principal of
King Edward Medical College in his presentation again emphasized the
usefulness of low dose aspirin therapy in all Type-2 diabetics since
they are at high risk of developing cardiovascular diseases as well.
Studies, he said, have shown that ten years before development of
diabetes, people are prone to develop cardiovascular diseases. Abdominal
obesity, hypertension, diabetes mellitus, dyslipidemais, chronic
cardiovascular diseases are all considered important risk factors. He
then talked about the clinical features of Type-2 diabetes. The patients
should be advised to control their hypertension, blood glucose, and
dyslipidemias. He suggested that all patients with previous myocardial
infarction, TIAs, vascular surgery, angioplasty must be put on low dose
Aspirin therapy. Majority of the Type-2 diabetics, he said, are high
risk patients.
Prof. Ejaz Ahmad Vohra another noted physician and Dean postgraduate
studies at Ziauddin Medical University in his presentation pointed out
that TIAs should be treated as an established Angina. Most of the
diabetics, he further stated, are killed because of cardiovascular
diseases. Unless there are some contra indications, all stroke patients
and those with TIAs should be prescribed low dose aspirin therapy for
secondary prevention.
Prof. Saeed Ahmad Sangi Prof.of Cardiology at Chandka Medical College
presented the futuristic vision of medicine. He felt that soon the
surgeons are expected to be out of job as robots will take up most of
the surgery. Artificial hearts will become available. Cardiovascular
medicine by 2034 will undergo drastic changes and after some time anti
obesity drugs will be available. Biotechnology is making tremendous
progress. It is expected that the incidence of myocardial infarction
will go down in the developing countries. Stem cells will become
available as standard procedures. There will be drastic reduction in
cardiac surgery as robotic surgery will be a reality. Artificial heart
replacement will become possible. Prof. Khalida Soomro Professor of
Cardiology at Dow University of Health Sciences was the next speaker in
this session who also talked about newer antiplatelet agents like GPIIb/IIIa.
Dr. Maqbool H. Jafary in his second presentation talked about the new
and emerging indications of Aspirin Therapy which include colorectal
cancer, gastric and esophageal cancer, Alzheimer’s disease, pregnancy
induced hypertension, renal disorders, pulmonary embolism, DVT etc.
During the discussion which followed rational use of antiplatelet
therapy in acute coronary syndrome was highlighted.
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Prof. Akbar Chaudhry takes over as
the
new President of Pakistan Aspirin Foundation
Prof. Javed Akram to organize the
next National Conference at Lahore in 2011 |
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LARKANA:
After consensus among the founder members, Prof. M. Akbar Chaudhry
former Principal of Fatima Jinnah Medical College and currently
Principal of Continental Medical College Lahore was selected as the
new President of Pakistan Aspirin Foundation. He replaced Dr.
Maqbool H. Jafary whose term expired this month. A decision to this
effect was taken at the General Body Meeting/consensus consultations
held before and during the recently held national conference of
Pakistan Aspirin Foundation at Larkana on October 31st 2009.
Prof. M. Akbar Chaudhry Principal
Continental Medical College and newly elected President of
Pakistan Aspirin Foundation presenting shields to Prof. Ejaz Ahmad
Vohra, Prof. Khalida Soomro and Prof. Javed Akram during the
national conference of Pakistan Aspirin Foundation held at SMBBMU/CMC
Larkana on October 31st 2009.
Prof. Akbar
Chaudhry, it may be mentioned here is the life member of Pakistan
Aspirin Foundation and has successfully organized one of the
National Conferences at FJMC. He has also been working as Central
Coordinator for Pakistan Aspirin Foundation for Punjab for the last
two years. Selection of the President is made keeping in view the
fact that the person selected must show his commitment, must have
time to coordinate and organize its Continuing Medical Education
programmes which involves lot of travelling to small cities and
towns all over the country. As per schedule and past traditions of
rotating Presidentship of the Foundation in different provinces,
this time it was the turn for some one from Punjab. Prof. Mumtaz
Hassan an eminent physician and former Principal of King Edward
Medical College was the first choice. However, he expressed his
inability due to some personal engagements but assured his support
for the CME activities. He further stated that he will fully support
Prof. Akbar Chaudhry and will be too glad to be one of the speakers
at the CME programmes.
Prof. Javed Akram Principal of Allama Iqbal Medical College was
selected as organizer for the next national conference which will be
held at Lahore during 2011. He is also a founder member of Pakistan
Aspirin Foundation. Keeping in view his organizational capabilities
the members were unanimous that we will have a very successful
meeting with good informative and interesting scientific programme
in 2011.
Mr. Ayaz Soomro Sindh Minister for Law
presenting shields to Mr. Munawar Abbasi MPA, Prof. Saeed
Ahmad Sangi, Prof. Asadullah Maher Principal CMC and Mr.
Shaukat Ali Jawaid General Secretary of Pakistan Aspirin
Foundation at the public awareness session on Aspirin at CMC
Larkana on October 31st 2009.
Organizing
this national conference at Larkana had been a very difficult task
due to the prevailing law and order situation in the country besides
inaccessibility. There are a few flights to Mohenjodaro Airport from
different cities in Pakistan and that too not daily. Hence, some of
the delegates from Lahore had to travel to Sukkur to reach Larkana
and managed to get their return flights from Sukkur to Karachi and
then Lahore which was quite inconvenient. However, it was their
dedication, devotion and commitment that they made it possible
despite difficult travel schedule.
Among the invited guest speakers and participants who travelled from
Karachi and Lahore to participate in the conference were Prof.
Mahmood Ali Malik former Principal of KEMC and founder President of
Pakistan Aspirin Foundation, Prof. M. Akbar Chaudhry Principal
Continental Medical College, Prof. Javed Akram Principal Allama
Iqbal Medical College, Prof. Talat Naheed Prof.of Medicine at FJMC.
From Karachi the speakers included Dr. Maqbool H. Jafary, President
of Pakistan Aspirin Foundation, Prof. Ejaz Ahmad Vohra Dean
Postgraduate Studies and Head of Dept. of Medicine at Ziauddin
Medical University, Prof. Zaman Sheikh Prof.of Medicine at DUHS and
Executive director of National Institute of Diabetes and
Endocrinology at Ojha Campus, Prof. Khalida Soomro from DUHS
Karachi, Mr. Shaukat Muttaki consultant pharmacist. The meeting was
also attended by some cardiologists from interior of Sindh besides
the faculty members of Sardar Ghulam Mohammad Maher Medical College
at Sukkur and Chandka Medical College, SMBBMU Larkana and students
of Chandka Medical College.
During the General Body meeting Prof. Mahmood Ali Malik, Prof. Akbar
Chaudhry and Dr. Maqbool H. Jafary recorded their appreciation for
Prof. Saeed Sangi for organizing this meeting at such a short
notice. They also put on record the efforts made by General
Secretary of Pakistan Aspirin Foundation Mr. Shaukat Ali Jawaid to
make it possible that the meetings are held as schedule. They also
expressed their gratitude to Atco Laboratories in general and its
focal person looking after Aspirin related activities Mr. Farhan
Raza Product Manager in Atco in particular and the entire ATCO team
for their hard work which helped to make the conference a success.
Dr. Maqbool H. Jafary thanked the members for their support during
his tenure as President and said that he tried his best to
contribute as much as possible. Apart from addressing various CME
meetings at Isra University in Hyderabad, KIHD in Karachi, small
towns and cities like Khanewal, Vehari, Sialkot, Sahiwal etc., a
booklet on Aspirin in Urdu was also published to create awareness
and promote the use of Aspirin. It is quite useful not only for the
public but also for the Family Physicians. Now efforts are being
made to translate this booklet in other regional languages. Prof.
Akbar Chaudhry speaking at the occasion sought help and assistance
from all the members so that we can carry forward the message and
thus promote the aims and objectives of Pakistan Aspirin Foundation.
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Public
awareness session on Aspirin
There is no dearth
of good doctors
in Larkana - Ayaz Soomro
Experts highlight safety and
efficacy of Aspirin in various diseases |
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LARKANA: There is no dearth of good
doctors in Larkana and many of them continue to serve the ailing
humanity with devotion and dedication. This was stated by Mr.
Ayaz Soomro Provincial Minister for Law, Government of Sindh. He
was speaking at the public awareness session during the national
conference of Pakistan Aspirin Foundation held here on October
31st 2009.
The meeting was largely attended by faculty members of SMBBMU,
CMC, medical students, and representatives of public and legal
profession. Also present on the occasion were Vice Chancellor of
SMBBMU Prof.Sikandar Sheikh, Mr. Abbasi MPA and Prof. Asadullah
Maher, Principal of Chandka Medical College.

Prof. Abrar Ahmad Sheikh Dean
Faculty of Medicine at SMBBMU Larkana chaired the first
scientific session during the national conference of
Pakistan Aspirin Foundation held at CMC on October 31st
2009. Picture shows him presenting conference mementoes to
the guest speakers from (L to R) Prof. Ejaz Ahmad Vohra,
Prof. Zaman Sheikh, Prof. M. Akbar Chaudhry and Prof.
Mahmood Ali Malik.
Mr. Ayaz Soomro thanked Pakistan
Aspirin Foundation for selecting Larkana as a venue for their
national conference and hoped that such academic activities will
be extremely beneficial not only for the healthcare
professionals but public as well. Larkana as a city, he said,
has been neglected for too long and so was the case with Chandka
Medical College. Our government has now given it the status of a
medical university named after late Mohtarma Benazir Bhutto and
in the days to come it will be an important medical institution
in this part of the country. Larkana has received four martyrs
of the Bhutto Family who are all buried in Naudero at Garhi
Khuda Bakhsh. Late Mr. Z.A. Bhutto the Prime Minister of
Pakistan laid the foundation of Pakistan’s atomic programme and
now we have become an atomic power quite capable of defending
ourselves against all sort of aggressions, he added.
Earlier eminent speakers which included Prof. Mahmood Ali Malik,
Prof. Akbar Chaudhry, and Dr. Maqbool H. Jafary highlighted the
safety and efficacy of Aspirin therapy in its well established
indications. This is an extremely cost effective drug which
significantly reduces morbidity and mortality when used under
instructions by the doctors. Prof.Mahmood Ali Malik opined that
all Type-2 diabetics must be put on low dose aspirin therapy for
indefinite period. Prof. Akbar Chaudhry stated that Aspirin is
extremely useful in a large number of cardiovascular diseases,
cerebrovascular diseases including Stroke and TIAs. Dr. Maqbool
H. Jafary outgoing President of Pakistan Aspirin Foundation said
that people should carry Aspirin tablets with them as they or
any one else might use it. As soon as on feels chest pain, one
full tablet of Aspirin 325mg should be chewed immediately or
soluble aspirin should be taken immediately. It will reduce the
chances of any mortality from heart attack by 25%. However, if
it is added with streptokinase, the mortality reduction is
almost over 40%.
Earlier Dr. Saeed Ahmad Sangi Prof. of Cardiology and convener
of the conference talking about future of medicine in general
and cardiology in particular referred to the startling changes
which might take place in the days to come. Addressing the
participants in Sindhi, he also highlighted the efficacy of
Aspirin in various diseases. This in fact was translation of the
Urdu Booklet on Aspirin authored by Dr. Maqbool H. Jafary and
Mr.Shaukat Ali Jawaid. The participants felt that the book
should also be translated in Sindhi and other regional
languages.
Replying to questions from the participants it was stated that
low dose aspirin is indicated in all patients after
interventional procedures like angioplasty and stenting. In case
some patients are allergic to aspirin, there are other anti
platelet agents which are of course expensive but quite
effective. Combination of Aspirin and Clopidogrel is also being
increasingly used in various diseases.
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Seminars on Aspirin Update
at Tando Adam Khan and Hala
Aspirin therapy is now also being
increasingly
used for primary
prevention of CAD
All high risk
patients with absolute ten years risk of
more than 15% must be prescribed Aspirin along
with other drugs - Dr. Maqbool H. Jafary
From our
correspondent
TANDO ADAM KHAN
AND HALA: While safety and efficacy of Aspirin therapy in
secondary prevention of coronary artery disease is well
established, it is now also being increasingly used in primary
prevention of cardiovascular diseases. This was stated by Dr.
Maqbool H. Jafary a noted physician and President of Pakistan
Aspirin Foundation. He was addressing seminars organized by
Pakistan Aspirin Foundation in collaboration with local PMA at
Tando Adam Khan and Hala on October 9th 2008. Both these
meetings were sponsored by Atco Laboratories as a service to
provide Continuing Medical Education for the healthcare
professionals.

A group
photograph of some of the participants to the seminar on
Aspirin Update and local PMA office bearers photographed along
with the speakers at Taulka Hospital Tando Adam Khan
In his
comprehensive presentation on Aspirin Update titled as Aspirin-
the Wonder Drug, Dr. Maqbool H. Jafary first traced the
historical back ground and discussed at length that how Dr.Flex
Hoffman discovered this agent. At present 37.6% of Aspirin is
being used in cardiovascular diseases and more than hundred
billion tablets are consumed annually. It was Dr. Peter Elwood a
Scottish Physician who did pioneering work as regards use of
aspirin in cardiovascular diseases and showed in 1974 that it
prevents myocardial infarction. Now Aspirin is being used for
not only secondary prevention but also primary prevention of
cardiovascular diseases. There are numerous studies to prove
that all high risk patients with absolute ten years risk of more
than 15% must be prescribed Aspirin therapy along with other
drugs. If the ten years absolute risk is less than 6%, no
aspirin is required but if this risk is between 7-14% it should
he left at patient choice. Obese patients, those with family
history of cardiovascular disease, those suffering from high
blood pressure, diabetics all come into high risk group.

Pakistan
Aspirin Foundation in collaboration with PMA Tando Adam Khan
organized a seminar on Aspirin Update on October 9th
2008. Picture shows Dr. Maqbool H. Jafary President of PAF,
Dr. Gada Husssain Bhellr, Mr. Shaukat Ali Jawaid, Dr. Abdul
Hameed Ghauri and Dr. Bashir Khaskheli speaking at the
occasion.
As regards
secondary prevention of cardiovascular diseases, numerous
studies has shown that it reduces non-fatal MI by 32%; non-fatal
strokes by 27%, total cardiovascular mortality by 15% and
vascular events by 15%. In case of acute myocardial infarction
the patient must be advised to take a full tablet of aspirin
immediately chew it or use soluble aspirin followed by 75mg of
enteric coated Aspirin indefinitely unless there are contra
indications. Aspirin therapy alone reduces 25% mortality in AMI
if taken immediately but if it is combined with streptokinase
within six hours, the mortality reduction is increased to 42%.
Most often there is no increased risk of bleeding. In Acute
Coronary Syndromes risk of another MI and death is reduced by
50% as shown in ISIS-II study.
Talking about
the use of Aspirin therapy in stroke, Dr. Jafary pointed out
that 150-300mg of Aspirin is the drug of choice within forty
eight hours. He made it clear that even if it is hemorrhagic
stroke, one tablet of 300mg used immediately in case of
myocardial infarction is not going to do much harm but it can
prove to be life saving. Once the patient is stable, then
investigations can be undertaken to determine whether it is
ischaemic or hemorrhagic stroke. Aspirin has proven benefits in
secondary prevention of secondary strokes. In high risk
individuals, Aspirin is combined with clopidogrel which ensures
20% relative risk reduction of second MI or stroke. In patients
who have had intervention procedures like angioplasty or
stenting, combination of Aspirin and Clopidogrel is used unless
there is some contra indication. Regarding its use in
hypertension, it is important that first blood pressure should
be controlled and then the patient should be put on Aspirin
therapy. All Type-2 diabetics should also be put on regular
aspirin therapy, he added.

Some
office bearers of PMA Hala and participants to Aspirin
seminar photographed after the meeting on October 9th
2008.
He then briefly
discussed the emerging indications for use of Aspirin therapy
like colorectal cancer, esophageal and gastric cancer, pulmonary
embolism, DVT, renal diseases etc. He also briefly referred to
the ARRIVE study which will enroll over twelve thousand patients
at four hundred centers in five countries which will complete in
2013. It will provide sufficient evidence regarding use of
Aspirin therapy in primary prevention of coronary artery
diseases, he added.
Responding to
various questions Dr. Jafary stated that Experts Panel of
Pakistan Aspirin Foundation in its Consensus Statement on
Medical Uses of Aspirin has clearly stated the dosage,
indications and contra indications for use of Aspirin. Copies of
this consensus statement will be distributed among the
participants later and they are also available on the website of
Pakistan Aspirin Foundation.(www.pakaspirin.org)

On left
Dr. Maqbool H. Jafary President Pakistan Aspirin Foundation
presenting Life Membership shield to Dr. Abdul Hameed Ghauri
while other pictures show guests being presented traditional
Sindhi Ajrak and flowers during the seminar on Aspirin Update
held at Tando Adam Khan recently.
Dr. Abdul
Hameed Ghauri in charge of Coronary Care Unit at the local
hospital in his presentation pointed out that there is need to
educate the healthcare professionals on the safety and efficacy
of Aspirin in cardiovascular diseases. It has proved to be a
life saving drug. We as cardiologists are aware of its benefits
though it is still being under used. A vast majority of deaths
in the developing countries, he said, are due to cardiovascular
diseases and hypertension requires life long therapy. The
doctors need to be updated on preventive properties of anti
platelet and anti cholesterol drugs. We can prevent a large
number of these deaths by taking simple measures, life style
modification, use of healthy diet and appropriate drugs. GPs, he
said, play an important role in health delivery system hence
they need to be kept update through such CME programmes.
Dr. Maqbool H.
Jafary emphasized upon the family physicians that they must
ensure more and more use of Aspirin in its well established
indications. The Aspirin Awareness and Usage Study (AAUS)
conducted by Pakistan Aspirin Foundation which enrolled over
fourteen hundred ACS patients in seventeen coronary care units
across the country showed that only 16% patients used Aspirin
therapy at home and only 20% of the GPs prescribed Aspirin while
only 52% of the patients discharged from the CCUs were
prescribed aspirin along with other drugs. This is a very dismal
picture and we need to improve it for the safety of the
patients, he added.
The meeting at
Tando Adam Khan was also attended by healthcare professionals
from Shahdadpur and other adjoining areas and they showed keen
interest and wished that a similar programme should be organized
at Shahdadpur as well.
Earlier Mr.
Shaukat Ali Jawaid General Secretary of Pakistan Aspirin
Foundation highlighted the activities and accomplishments of the
Pakistan Aspirin Foundation. He made is clear that they do not
promote any particular brand of Aspirin keeping up professional
ethics. He however thanked Atco Laboratories and their
cardiovascular team headed by Mr. Akhtar and Product Manager Mr.
Farhan Raza for making arrangements to sponsor CME programmes of
the Pakistan Aspirin Foundation for the last many years.
Dr.Bashir Khaskheli General Secretary PMA welcomed the speakers
and the participants of the seminar. Dr. Gadda Hussian Bheller
In charge of Taulka Hospital Tando Adam Khan, President of local
PMA and Medical Supdt. of Shahdadpur Taulka Hospital presented
traditional Sindhi Ajrak among the guest speakers. The meeting
was conducted by Mr. Farhan Raza Product Manager from Atco
Laboratories while Mr. Akhtar Business Unit Head of Cardiology
in Atco was also present on the occasion.
At Hala, the
meeting was chaired by Dr. Abdul Rashid Memon President elect of
Hala PMA while the programme was conducted by Dr. Ateeque. Guest
speakers and the participants were welcomed by Dr. Abdul Sattar
Meer General Secretary of Hala PMA.
Presentation by
Dr. Maqbool H. Jafary was followed by lively discussion.
Replying to a question regarding role of Aspirin in smokers,
Dr.Jafary said that smoking is an important risk factor in
coronary artery disease and hypertension; hence Aspirin has a
role in these people. Responding to another question he said
that as a rule, all such drugs must be avoided during pregnancy,
Aspirin is no exception. If there is a need, some other pain
killer like paracetamol can be used. Some experts say that in
case of IHD, one can continue Aspirin therapy during pregnancy
but if one can avoid it, it is much better. Regarding effects of
Aspirin on liver, Dr. Jafary said it has no effect and it does
not disturb liver enzymes. In case of fatty liver, one must look
at the back ground like obesity. These are some of the
manifestations in pre diabetic stage and these patients will
eventually develop diabetes. As a primary prevention one can use
Aspirin particularly if other risk factors are also present.
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